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Adult polyglucosan body disease (APBD) is an autosomal recessive leukodystrophy caused by abnormal intracellular accumulation of glycogen byproducts.





There are five types of GSD IV, which are . The diagnosis can be made by nerve biopsy.

Signs and symptoms include trouble walking due to peripheral neuropathy and muscle weakness and stiffness.

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To examine the frequency of …. Adult polyglucosan body disease (APBD) may represent a neuropathological hallmark of the adult form of this storage disease of the central nervous system and patients develop upper and lower neuron disease and dementia, probably secondary to the disruption of neuron and astrocyte functions.

Adult polyglucosan body disease (APBD) represents a complex autosomal recessive inherited neurometabolic disorder due to homozygous or compound heterozygous …. The adult-onset form of GSD IV, referred to as adult polyglucosan body disease (APBD), is a neurodegenerative disease characterized by neurogenic bladder, spastic paraparesis, and peripheral neuropathy. GBE activity was decreased in the morphologically affected tissues but was normal in unaffected tissues.

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Similar biochemical finding is shared by glycogen storage disease type IV (GSD IV) that, in contrast to APBD, is an early childhood .

We describe three Italian siblings at disease onset, presenting in their fifties with a combination of pyramidal and ataxic signs, mild demyelinating neuropathy on .

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Adult polyglucosan body disease (APBD) is a late-onset disease caused by intracellular accumulation of polyglucosan bodies, formed due to glycogen-branching enzyme (GBE) deficiency. 1002/ana. org Phone: 646.



Adult polyglucosan body disease is an orphan disease and a glycogen storage disorder that is caused by an inborn error of metabolism, that affects the central and peripheral nervous systems.





Adult Polyglucosan Body Disease (APBD) is a rare inherited leukodystrophy associated with axonal polyneuropathy, mainly reported in persons of Ashkenazi-Jewish descent. Apr 2, 2009 · GBE1 adult polyglucosan body disease ( GBE1- APBD) should be considered in individuals with the following clinical findings, neuroimaging findings, family history, and ethnicity. From MedlinePlus Genetics Adult polyglucosan body disease (APBD) is a condition that affects the nervous system.

Initial symptoms of the disorder include numbness and tingling in the legs (peripheral neuropathy) and progressive muscle weakness and stiffness .







, spasticity and weakness) from mixed upper and lower motor neuron involvement, sensory loss predominantly in the distal lower extremities, autonomic dysfunction (associated with orthostatic hypotension and . Adult polyglucosan body disease (APBD) is an autosomal recessive leukodystrophy characterized by neurogenic bladder, progressive spastic gait, and peripheral neuropathy.

. Adult Polyglucosan Body Disease (APBD) is a neuromuscular, adult-onset form of glycogen storage disease type IV (GSD IV).



Autopsy of a 50-year-old woman with adult polyglucosan body disease and missense mutations (Arg515His, Arg524Gln) in the glycogen branching enzyme gene ( GBE) revealed accumulation of polyglucosan bodies in the heart, brain, and nerve. A glycogen storage disease of adults characterized by progressive upper and lower motor neuron dysfunction, progressive neurogenic bladder and cognitive difficulties that can lead to dementia.